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The antibody against SLC38A9 was raised in rabbit using the Recombinant Human Sodium-coupled neutral amino acid transporter 9 protein (1-119AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
The antibody against SLC38A9 was raised in rabbit using the Recombinant Human Sodium-coupled neutral amino acid transporter 9 protein (1-119AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
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Immunohistochemistry of paraffin-embedded human liver tissue using SLC38A9 Antibody at dilution of 1:1002
| Cat.No | ADC-15154A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SLC38A9 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Sodium-coupled neutral amino acid transporter 9 protein (1-119AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8NBW4 |
Uniprot Id
Q8NBW4
Target Species
Human
Target Name
SLC38A9
Target Full Name
Neutral amino acid transporter 9
Target Function
Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of amino acids with low capacity and specificity with a slight preference for polar amino acids. Acts as an arginine sensor. Following activation by arginine binding, mediates transport of leucine, tyrosine and phenylalanine with high efficiency, and is required for the efficient utilization of these amino acids after lysosomal protein degradation.
Target Subcellular Location
Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein.
Target Protein Families
Amino acid/polyamine transporter 2 family, SLC38A9 subfamily
Target Synonyms
FLJ46104; FLJ90709; Homo sapiens solute carrier family 38; member 9; MGC120544; OTTHUMP00000161835; Putative sodium coupled neutral amino acid transporter 9; Putative sodium-coupled neutral amino acid transporter 9; Putative uncharacterized protein FLJ90709 ; S38A9_HUMAN; SLC38A9
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