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The antibody against SLC6A3 was raised in rabbit using the Synthetic peptide of Human SLC6A3 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against SLC6A3 was raised in rabbit using the Synthetic peptide of Human SLC6A3 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
$299.00
| Cat.No | ADC-28603A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SLC6A3 |
| Target Synonyms | member 3 antibody; Solute carrier family 6 (neurotransmitter transporter), member 3 antibody; Solute carrier family 6 member 3 antibody; Variable number tandem repeat (VNTR) antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 0.05% NaN3, 40% Glycerol., pH7.4 PBS | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Synthetic peptide of Human SLC6A3 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q01959 |
Uniprot Id
Q01959
Target Species
Human
Target Name
SLC6A3
Target Full Name
Sodium-dependent dopamine transporter
Target Function
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals. Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling.
Target Involvement
Parkinsonism-dystonia infantile (PKDYS)
Target Subcellular Location
Cell membrane; Multi-pass membrane protein. Cell projection, neuron projection.
Target Protein Families
Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A3 subfamily
Target Tissue Specificity
Highly expressed in substantia nigra.
Target Synonyms
DAT; DAT1; PKDYS; PKDYS1; Dopamine Transporter/SLC6A3
Target Background
This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.
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