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The antibody against SMC5 was raised in rabbit using the Recombinant Human Structural maintenance of chromosomes protein 5 protein (296-403AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
The antibody against SMC5 was raised in rabbit using the Recombinant Human Structural maintenance of chromosomes protein 5 protein (296-403AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
$299.00
| Cat.No | ADC-05621A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SMC5 |
| Target Synonyms | SMC5 antibody; KIAA0594 antibody; SMC5L1 antibody; Structural maintenance of chromosomes protein 5 antibody; SMC protein 5 antibody; SMC-5 antibody; hSMC5 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Structural maintenance of chromosomes protein 5 protein (296-403AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8IY18 |
Uniprot Id
Q8IY18
Target Species
Human
Target Name
SMC5
Target Full Name
Structural maintenance of chromosomes protein 5
Target Function
Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome.
Target Subcellular Location
Nucleus. Chromosome. Nucleus, PML body. Chromosome, telomere.
Target Protein Families
SMC family, SMC5 subfamily
Target Tissue Specificity
Widely expressed. Strongly expressed in testis.
Target Synonyms
SMC5; KIAA0594; SMC5L1; Structural maintenance of chromosomes protein 5; SMC protein 5; SMC-5; hSMC5
Target Background
Predicted to enable ATP binding activity. Involved in several processes, including DNA recombination; cellular senescence; and positive regulation of maintenance of mitotic sister chromatid cohesion. Located in cell junction; chromosome; and nuclear body. Part of Smc5-Smc6 complex.
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