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The antibody against SMG6 was raised in rabbit using the Recombinant Human Telomerase-binding protein EST1A protein (251-511AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against SMG6 was raised in rabbit using the Recombinant Human Telomerase-binding protein EST1A protein (251-511AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
$299.00
Immunohistochemistry of paraffin-embedded human gastric cancer using SMG6 Antibody at dilution of 1:100
Immunohistochemistry analysis of human endometrial cancer using SMG6 Antibody at dilution of 1:1002
Immunofluorescent analysis of MCF-7 cells using SMG6 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)3
| Cat.No | ADC-19437A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SMG6 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Telomerase-binding protein EST1A protein (251-511AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q86US8 |
Uniprot Id
Q86US8
Target Species
Human
Target Name
SMG6
Target Full Name
Telomerase-binding protein EST1A
Target Function
Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regulation. Promotes in vitro the ability of TERT to elongate telomeres. Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization. Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER).; Plays a role in nonsense-mediated mRNA decay. Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA.
Target Subcellular Location
Nucleus, nucleolus. Chromosome, telomere. Cytoplasm, cytosol. Note=Particularly enriched in the nucleolus.
Target Tissue Specificity
Ubiquitous.
Target Research Area
Cancer
Target Synonyms
SMG6; C17orf31; EST1A; KIAA0732Telomerase-binding protein EST1A; EC 3.1.-.-; EST1-like protein A; Ever shorter telomeres 1A; Smg-6 homolog; Telomerase subunit EST1A; hSmg5/7a
Target Background
This gene encodes a component of the telomerase ribonucleoprotein complex responsible for the replication and maintenance of chromosome ends. The encoded protein also plays a role in the nonsense-mediated mRNA decay (NMD) pathway, providing the endonuclease activity near the premature translation termination codon that is needed to initiate NMD. Alternatively spliced transcript variants encoding distinct protein isoforms have been described.
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