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The antibody against SMG7 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human SMG7. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, IF, ELISA.
The antibody against SMG7 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human SMG7. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, IF, ELISA.
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Western Blot analysis of HuvEc cells using SMG7 Polyclonal Antibody
Western Blot analysis of Jurkat cells using SMG7 Polyclonal Antibody2
| Cat.No | ADC-37600A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SMG7 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the Internal region of Human SMG7. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q92540 |
Uniprot Id
Q92540
Target Species
Human
Target Name
SMG7
Target Full Name
Nonsense-mediated mRNA decay factor SMG7
Target Function
Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation.
Target Subcellular Location
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm.
Target Synonyms
breast cancer-associated antigen SGA-56M; C1orf16; EST1 like protein C; EST1 telomerase component homolog C; EST1-like protein C; EST1C; ever shorter telomeres 1C; FLJ23717; hSMG-7; nonsense mediated mRNA decay factor (C. elegans); Protein SMG7; SGA56M; SMG 7; SMG-7 homolog; Smg7; SMG7_HUMAN
Target Background
This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
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