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The antibody against SMYD2 was raised in rabbit using the Recombinant Human N-lysine methyltransferase SMYD2 protein (115-272AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against SMYD2 was raised in rabbit using the Recombinant Human N-lysine methyltransferase SMYD2 protein (115-272AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human testis tissue using SMYD2 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human small intestine tissue using SMYD2 Antibody at dilution of 1:1002
Immunofluorescent analysis of Hela cells using SMYD2 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)3
| Cat.No | ADC-14917A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SMYD2 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human N-lysine methyltransferase SMYD2 protein (115-272AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9NRG4 |
Uniprot Id
Q9NRG4
Target Species
Human
Target Name
SMYD2
Target Full Name
N-lysine methyltransferase SMYD2
Target Function
Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.
Target Subcellular Location
Cytoplasm, cytosol. Nucleus.
Target Protein Families
Class V-like SAM-binding methyltransferase superfamily
Target Synonyms
Histone methyltransferase SMYD2; HSKM B; HSKM-B; HSKMB; KMT3C; Lysine N-methyltransferase 3C; MGC119305; N lysine methyltransferase SMYD2; N-lysine methyltransferase SMYD2; SET and MYND domain containing 2; SET and MYND domain containing protein 2; SET and MYND domain-containing protein 2; Smyd2; SMYD2_HUMAN; Zinc finger MYND domain containing 14; ZMYND14
Target Background
SET domain-containing proteins, such as SMYD2, catalyze lysine methylation (Brown et al., 2006 [PubMed 16805913]).
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