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The antibody against SMYD3 was raised in rabbit using the Recombinant Human Histone-lysine N-methyltransferase SMYD3 protein (199-428AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against SMYD3 was raised in rabbit using the Recombinant Human Histone-lysine N-methyltransferase SMYD3 protein (199-428AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
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Immunohistochemistry of paraffin-embedded human breast cancer using SMYD3 Antibody at dilution of 1:1002
| Cat.No | ADC-44160A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SMYD3 |
| Target Synonyms | 1 antibody; ZMYND 1 antibody; ZMYND1 antibody; ZNFN3A1 antibody, subfamily 3A (MYND domain containing) | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Histone-lysine N-methyltransferase SMYD3 protein (199-428AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9H7B4 |
Uniprot Id
Q9H7B4
Target Species
Human
Target Name
SMYD3
Target Full Name
Histone-lysine N-methyltransferase SMYD3
Target Function
Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. Also methylates 'Lys-5' of histone H4. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences.
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family
Target Tissue Specificity
Expressed in skeletal muscles and testis. Overexpressed in a majority of colorectal and hepatocellular carcinomas.
Target Research Area
Cancer
Target Synonyms
bA74P14.1 (novel protein); bA74P14.1; FLJ21080; histone lysine N methyltransferase SMYD3; KMT3E; MGC104324; SET and MYND domain containing 3; SET and MYND domain containing protein 3; SET and MYND domain-containing protein 3; SMYD 3; Smyd3; SMYD3 protein; SMYD3_HUMAN; Zinc finger MYND domain containing 1; Zinc finger MYND domain containing protein 1; Zinc finger MYND domain-containing protein 1; Zinc finger protein subfamily 3A MYND domain containing 1; Zinc finger protein, subfamily 3A (MYND domain containing), 1; ZMYND 1; ZMYND1; ZNFN3A1
Target Background
This gene encodes a histone methyltransferase which functions in RNA polymerase II complexes by an interaction with a specific RNA helicase. Multiple transcript variants encoding different isoforms have been found for this gene.
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