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The antibody against SNAP91 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 321-600 of human SNAP91 (NP_001229723.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against SNAP91 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 321-600 of human SNAP91 (NP_001229723.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-02862A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SNAP91 |
| Target Synonyms | CALM; AP180; SNAP91 | Form | Liquid |
| Species Reactivity | Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat brain, Mouse brain, Rat liver | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 321-600 of human SNAP91 (NP_001229723.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | O60641 | Immunogen Sequence |
Uniprot Id
O60641
Target Species
Human
Target Name
SNAP91
Target Full Name
Clathrin coat assembly protein AP180
Target Function
Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats.
Target Subcellular Location
Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side.
Target Protein Families
PICALM/SNAP91 family
Target Synonyms
SNAP91; KIAA0656Clathrin coat assembly protein AP180; 91 kDa synaptosomal-associated protein; Clathrin coat-associated protein AP180; Phosphoprotein F1-20
Target Background
Predicted to enable several functions, including SNARE binding activity; clathrin binding activity; and phosphatidylinositol binding activity. Acts upstream of or within regulation of clathrin-dependent endocytosis. Predicted to be located in several cellular components, including postsynaptic density; presynaptic endosome; and presynaptic membrane. Predicted to be extrinsic component of endosome membrane. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; cytoplasmic vesicle; and parallel fiber to Purkinje cell synapse. Predicted to be extrinsic component of presynaptic endocytic zone membrane. Biomarker of Alzheimer's disease.
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