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The antibody against SNX15 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-342 of human SNX15 (NP_037438.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against SNX15 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-342 of human SNX15 (NP_037438.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-01038A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SNX15 |
| Target Synonyms | HSAF001435; SNX15 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HepG2, Jurkat, Mouse spleen, Raji, U-87MG | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-342 of human SNX15 (NP_037438.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9NRS6 | Immunogen Sequence |
Uniprot Id
Q9NRS6
Target Species
Human
Target Name
SNX15
Target Full Name
Sorting nexin-15
Target Function
May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN.
Target Subcellular Location
Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
Target Protein Families
Sorting nexin family
Target Tissue Specificity
Widely expressed.
Target Synonyms
Clone iota unknown protein; HSAF001435; SNX 15; SNX15; SNX15_HUMAN; Sorting nexin 15; Sorting nexin-15
Target Background
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene.
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