Rabbit anti-Human SOCS2 Polyclonal Antibody

Uniprot Id

O14508

Target Species

Human

Target Name

SOCS2

Target Full Name

Suppressor of cytokine signaling 2

Target Function

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Target Tissue Specificity

High expression in heart, placenta, lung, kidney and prostate. Predominantly expressed in pulmonary epithelia cells, specifically type II pneumocytes.

Target Research Area

Immunology

Target Synonyms

CIS 2; CIS-2; CIS2; Cish 2; Cish2; Cytokine inducible SH2 protein 2; Cytokine-inducible SH2 protein 2; SOCS 2; SOCS-2; Socs2; SOCS2_HUMAN; SSI 2; SSI-2; SSI2; STAT induced STAT inhibitor 2; STAT-induced STAT inhibitor 2; STATI 2; STATI2; Suppressor of cytokine signaling 2

Target Background

This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants.