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The antibody against SOS1 was raised in rabbit using the Recombinant Human Son of sevenless homolog 1 protein (1140-1281AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
The antibody against SOS1 was raised in rabbit using the Recombinant Human Son of sevenless homolog 1 protein (1140-1281AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
$299.00
| Cat.No | ADC-04859A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SOS1 |
| Form | Liquid | Species Reactivity | Human, Rat |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Son of sevenless homolog 1 protein (1140-1281AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q07889 |
Uniprot Id
Q07889
Target Species
Human
Target Name
SOS1
Target Full Name
Son of sevenless homolog 1
Target Function
Promotes the exchange of Ras-bound GDP by GTP. Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF. Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity.
Target Involvement
Fibromatosis, gingival, 1 (GINGF1); Noonan syndrome 4 (NS4)
Target Tissue Specificity
Expressed in gingival tissues.
Target Synonyms
GF1; HGF; NS4; GGF1; GINGF; SOS-1; SOS1
Target Background
This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4.
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