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The antibody against SOX11 was raised in rabbit using the Recombinant Human Transcription factor SOX-11 protein (241-341AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against SOX11 was raised in rabbit using the Recombinant Human Transcription factor SOX-11 protein (241-341AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
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Immunohistochemistry of paraffin-embedded human liver cancer using SOX11 Antibody at dilution of 1:1002
| Cat.No | ADC-08354A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SOX11 |
| Target Synonyms | MRD27 antibody; SOX11 antibody; SOX11_HUMAN antibody; SRY (sex determining region Y) box 11 antibody; SRY related HMG box gene 11 antibody; SRY-box 11 antibody; Transcription factor SOX-11 antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Transcription factor SOX-11 protein (241-341AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P35716 |
Uniprot Id
P35716
Target Species
Human
Target Name
SOX11
Target Full Name
Transcription factor SOX-11
Target Function
Transcription factor that acts as a transcriptional activator. Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation. Acts as a transcriptional activator of TEAD2 by binding to its gene promoter and first intron. Plays a redundant role with SOX4 and SOX12 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis.
Target Involvement
Mental retardation, autosomal dominant 27 (MRD27)
Target Subcellular Location
Nucleus.
Target Tissue Specificity
Expressed primarily in the brain and heart, with low expression in the kidney, pancreas and muscle.
Target Synonyms
MRD27; SOX11; SOX11_HUMAN; SRY (sex determining region Y) box 11; SRY related HMG box gene 11; SRY-box 11; Transcription factor SOX-11
Target Background
This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis.
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