Rabbit anti-Human SOX2 Polyclonal Antibody

The antibody against SOX2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human SOX2 (NP_003097.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, IP, ELISA.

ADA-13032A

Number

Cat.No	ADA-13032A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	SOX2
Target Synonyms	ANOP3; MCOPS3; SOX2	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.05% proclin300, pH7.3.	Purification Method	Affinity purification
Positive Samples	Rat brain, 293T, MCF7, Mouse lung	Application	ELISA, WB, IF/ICC, IHC-P, IP

Cat.No

ADA-13032A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

SOX2

Target Synonyms

ANOP3; MCOPS3; SOX2

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.05% proclin300, pH7.3.

Purification Method

Affinity purification

Positive Samples

Rat brain, 293T, MCF7, Mouse lung

Application

ELISA, WB, IF/ICC, IHC-P, IP

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human SOX2 (NP_003097.1).	Target Species	Human
Immunogen Sequence	MYNMMETELKPPGPQQTSGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAPGGNSMA	Uniprot ID	P48431

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human SOX2 (NP_003097.1).

Target Species

Human

Immunogen Sequence

MYNMMETELKPPGPQQTSGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAPGGNSMA

Uniprot ID

P48431

Background Information

Uniprot Id

P48431
Target Species

Human
Target Name

SOX2
Target Full Name

Transcription factor SOX-2
Target Function

Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Binds to the proximal enhancer region of NANOG. Critical for early embryogenesis and for embryonic stem cell pluripotency. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development.
Target Involvement

Microphthalmia, syndromic, 3 (MCOPS3)
Target Subcellular Location

Nucleus.
Target Research Area

Transcription
Target Synonyms

ANOP3; cb236; Delta EF2a; lcc; MCOPS3; MGC148683; MGC2413; RGD1565646; Sex determining region Y box 2; SOX 2; Sox2; SOX2_HUMAN; SRY (sex determining region Y) box 2; SRY box containing gene 2; SRY related HMG box 2; SRY related HMG box gene 2; SRY-box 2; Transcription factor SOX 2; Transcription factor SOX-2; ysb
Target Background

This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).

Rabbit anti-Human SOX2 Polyclonal Antibody

Specifications

Immunogen Information

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