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The antibody against SPAG5 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human SPAG5 (NP_006452.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IF/ICC, ELISA.
The antibody against SPAG5 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human SPAG5 (NP_006452.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IF/ICC, ELISA.
Immunofluorescence analysis of HeLa cells using SPAG5 antibody. Blue: DAPI for nuclear staining.
| Cat.No | ADA-03015A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SPAG5 |
| Target Synonyms | MAP126; DEEPEST; hMAP126; SPAG5 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Application | ELISA, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human SPAG5 (NP_006452.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q96R06 | Immunogen Sequence |
Uniprot Id
Q96R06
Target Species
Human
Target Name
SPAG5
Target Full Name
Sperm-associated antigen 5
Target Function
Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes. Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2. In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis. May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU.
Target Subcellular Location
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Chromosome, centromere, kinetochore. Midbody. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic granule. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.
Target Tissue Specificity
Highly expressed in testis. Detected at low levels in placenta, liver, pancreas, thymus and colon.
Target Synonyms
Astrin; Deepest; hMAP 126; hMAP126; MAP 126; MAP126; Mitotic spindle associated protein; Mitotic spindle associated protein p126; Mitotic spindle coiled coil related protein; Mitotic spindle-associated protein p126; SPAG 5; SPAG5; SPAG5_HUMAN; Sperm associated antigen 5; Sperm tail protein Spag 5; Sperm tail protein Spag5; Sperm-associated antigen 5
Target Background
This gene encodes a protein associated with the mitotic spindle apparatus. The encoded protein may be involved in the functional and dynamic regulation of mitotic spindles.
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