Rabbit anti-Human SPAG8 Polyclonal Antibody

Uniprot Id

Q99932

Target Species

Human

Target Name

SPAG8

Target Full Name

Sperm-associated antigen 8

Target Function

Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5-regulated transcriptional activation of CREM isoform tau. Involved in the acrosome reaction and in binding of sperm to the zona pellucida. Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9.

Target Subcellular Location

Cytoplasm. Nucleus. Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasm, cytoskeleton, microtubule organizing center. Cytoplasm, cytoskeleton, spindle.

Target Protein Families

SPAG8 family

Target Tissue Specificity

Expressed in testis (germ cells), but not in liver, kidney, prostate and small intestine.

Target Synonyms

BS 84; CILD28; HSD 1; HSD-1; HSD1; hSMP1; MGC26201; MH SPAG8; OTTHUMP00000021352; OTTMUSP00000032209; SMP-1; SMP1; SPAG3; SPAG8; SPAG8_HUMAN; Sperm associated antigen 8; Sperm associated antigen 8 like protein; Sperm membrane protein 1; Sperm membrane protein BS-84; Sperm-associated antigen 8; Testicular tissue protein Li 177

Target Background

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein encoded by this gene is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. This protein interacts with ACT (activator of CREM in testis) and may play a role in CREM (cAMP response element modulator)-ACT-mediated gene transcription during spermatogenesis. This protein may also play a role in spermatogenesis by regulating microtubule formation and cell division. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined.