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The antibody against SPG21 was raised in rabbit using the Recombinant Human Maspardin protein (1-308AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against SPG21 was raised in rabbit using the Recombinant Human Maspardin protein (1-308AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human pancreatic cancer using SPG21 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human liver cancer using SPG21 Antibody at dilution of 1:1002
Immunofluorescent analysis of A549 cells using SPG21 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)3
| Cat.No | ADC-17819A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SPG21 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Maspardin protein (1-308AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9NZD8 |
Uniprot Id
Q9NZD8
Target Species
Human
Target Name
SPG21
Target Full Name
Maspardin
Target Function
May play a role as a negative regulatory factor in CD4-dependent T-cell activation.
Target Involvement
Spastic paraplegia 21, autosomal recessive (SPG21)
Target Subcellular Location
Cytoplasm, cytosol. Membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Note=Partially localized in the cytosol but also accumulated on an intracellular vesicular compartment. Colocalizes with CD4 on endosomal/trans-Golgi network.
Target Protein Families
AB hydrolase superfamily
Target Tissue Specificity
Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in J.CaM1.6, HuT 78 and HeLa cell lines (at protein level).
Target Synonyms
SPG21; ACP33; BM-019; GL010; Maspardin; Acid cluster protein 33; Spastic paraplegia 21 autosomal recessive Mast syndrome protein; Spastic paraplegia 21 protein
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