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The antibody against SPINK1 was raised in rabbit using the Recombinant Human Serine protease inhibitor Kazal-type 1 protein (19-79AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against SPINK1 was raised in rabbit using the Recombinant Human Serine protease inhibitor Kazal-type 1 protein (19-79AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
$299.00
Immunohistochemistry of paraffin-embedded human pancreatic tissue using SPINK1 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human colon cancer using SPINK1 Antibody at dilution of 1:1002
Immunofluorescent analysis of Hela cells using SPINK1 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)3
| Cat.No | ADC-14521A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SPINK1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Serine protease inhibitor Kazal-type 1 protein (19-79AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P00995 |
Uniprot Id
P00995
Target Species
Human
Target Name
SPINK1
Target Full Name
Serine protease inhibitor Kazal-type 1
Target Function
Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin-catalyzed premature activation of zymogens.; In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production.
Target Involvement
Pancreatitis, hereditary (PCTT); Tropical calcific pancreatitis (TCP)
Target Subcellular Location
Secreted.
Target Research Area
Cell Biology
Target Synonyms
ISK1_HUMAN; Pancreatic secretory trypsin inhibitor; Pancreatic serine protease inhibitor Kazal; PCTT; PSTI; Serine protease inhibitor Kazal type 1; Serine protease inhibitor Kazal-type 1; Spink 3; SPINK1; Spink3; TaTI; TCP; Tumor associated trypsin inhibitor; Tumor-associated trypsin inhibitor
Target Background
The protein encoded by this gene is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis.
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