Rabbit anti-Human SPRY2 Polyclonal Antibody

The antibody against SPRY2 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-100 of human SPRY2 (NP_005833.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-11327A

Number

Cat.No	ADA-11327A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	SPRY2
Target Synonyms	IGAN3; hSPRY2; SPRY2	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	Mouse heart, Jurkat, U-251MG	Application	ELISA, WB, IHC-P

Cat.No

ADA-11327A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

SPRY2

Target Synonyms

IGAN3; hSPRY2; SPRY2

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

Mouse heart, Jurkat, U-251MG

Application

ELISA, WB, IHC-P

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SPRY2 (NP_005833.1).	Target Species	Human
Immunogen Sequence	MEARAQSGNGSQPLLQTPRDGGRQRGEPDPRDALTQQVHVLSLDQIRAIRNTNEYTEGPTVVPRPGLKPAPRPSTQHKHERLHGLPEHRQPPRLQHSQVH	Uniprot ID	O43597

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SPRY2 (NP_005833.1).

Target Species

Human

Immunogen Sequence

MEARAQSGNGSQPLLQTPRDGGRQRGEPDPRDALTQQVHVLSLDQIRAIRNTNEYTEGPTVVPRPGLKPAPRPSTQHKHERLHGLPEHRQPPRLQHSQVH

Uniprot ID

O43597

Background Information

Uniprot Id

O43597
Target Species

Human
Target Name

SPRY2
Target Full Name

Protein sprouty homolog 2
Target Function

Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2. Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis. Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells. Inhibits CBL/C-CBL-mediated EGFR ubiquitination.
Target Involvement

IgA nephropathy 3 (IGAN3)
Target Subcellular Location

Cytoplasm, cytoskeleton. Cell projection, ruffle membrane.
Target Protein Families

Sprouty family
Target Research Area

Cardiovascular
Target Synonyms

hSPRY 2; hSPRY2; MGC23039; Protein sprouty homolog 2; Sprouty 2; Sprouty homolog 2 (Drosophila); Sprouty homolog 2; Sprouty2; Spry 2; Spry-2; SPRY2; SPY2_HUMAN
Target Background

This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein.

Rabbit anti-Human SPRY2 Polyclonal Antibody

Specifications

Immunogen Information

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