Rabbit anti-Human SPTLC2 Polyclonal Antibody

The antibody against SPTLC2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 423-562 of human SPTLC2 (NP_004854.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-09217A

Number

Cat.No	ADA-09217A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	SPTLC2
Target Synonyms	LCB2; SPT2; HSN1C; LCB2A; NSAN1C; hLCB2a; SPTLC2	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	Mouse kidney, 293T, BxPC-3, Mouse stomach, U-87MG	Application	ELISA, WB

Cat.No

ADA-09217A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

SPTLC2

Target Synonyms

LCB2; SPT2; HSN1C; LCB2A; NSAN1C; hLCB2a; SPTLC2

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

Mouse kidney, 293T, BxPC-3, Mouse stomach, U-87MG

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 423-562 of human SPTLC2 (NP_004854.1).	Target Species	Human
Immunogen Sequence	MKCIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIGAFGREMLKRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKYSRHRLVPLLDRPFDETTYEETED	Uniprot ID	O15270

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 423-562 of human SPTLC2 (NP_004854.1).

Target Species

Human

Immunogen Sequence

MKCIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIGAFGREMLKRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKYSRHRLVPLLDRPFDETTYEETED

Uniprot ID

O15270

Background Information

Uniprot Id

O15270
Target Species

Human
Target Name

SPTLC2
Target Full Name

Serine palmitoyltransferase 2
Target Function

Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate. Plays an important role in de novo sphyngolipid biosynthesis which is crucial for adipogenesis.
Target Involvement

Neuropathy, hereditary sensory and autonomic, 1C (HSAN1C)
Target Subcellular Location

Endoplasmic reticulum membrane; Single-pass membrane protein.
Target Protein Families

Class-II pyridoxal-phosphate-dependent aminotransferase family
Target Tissue Specificity

Widely expressed.
Target Research Area

Cancer
Target Synonyms

KIAA0526; LCB 2; LCB2; LCB2a; Long chain base biosynthesis protein 2; Long chain base biosynthesis protein 2a; Serine palmitoyl CoA transferase 2; Serine palmitoyltransferase 2; Serine palmitoyltransferase long chain base subunit 2; Serine palmitoyltransferase subunit II; Serine-palmitoyl-CoA transferase 2; SPT 2; SPT2; SPTC2_HUMAN; SPTLC 2; Sptlc2
Target Background

This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I.

Rabbit anti-Human SPTLC2 Polyclonal Antibody

Specifications

Immunogen Information

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