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The antibody against SRRM4 was raised in rabbit using the Recombinant Human Serine/arginine repetitive matrix protein 4 protein (400-479AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against SRRM4 was raised in rabbit using the Recombinant Human Serine/arginine repetitive matrix protein 4 protein (400-479AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
$299.00
| Cat.No | ADC-05139A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SRRM4 |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Serine/arginine repetitive matrix protein 4 protein (400-479AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | A7MD48 |
Uniprot Id
A7MD48
Target Species
Human
Target Name
SRRM4
Target Full Name
Serine/arginine repetitive matrix protein 4
Target Function
Splicing factor specifically required for neural cell differentiation. Acts in conjunction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural-specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts. Promotes alternative splicing of REST transcripts to produce REST isoform 3 (REST4) with greatly reduced repressive activity, thereby activating expression of REST targets in neural cells. Plays an important role during embryonic development as well as in the proper functioning of the adult nervous system. Regulates alternative splicing events in genes with important neuronal functions.
Target Subcellular Location
Nucleus.
Target Protein Families
NSR100 family
Target Tissue Specificity
Specifically expressed in neuronal cells (at protein level). Expressed in the cerebellum.
Target Synonyms
SRRM4; KIAA1853; Serine/arginine repetitive matrix protein 4; Medulloblastoma antigen MU-MB-2.76; Neural-specific serine/arginine repetitive splicing factor of 100 kDa; Neural-specific SR-related protein of 100 kDa; nSR100
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