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The antibody against SRRT was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 623-872 of human SRRT (NP_001122325.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IHC-P, ELISA.
The antibody against SRRT was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 623-872 of human SRRT (NP_001122325.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IHC-P, ELISA.
Immunohistochemistry analysis of paraffin-embedded rat liver using SRRT antibody at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
| Cat.No | ADA-10486A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SRRT |
| Target Synonyms | ARS2; ASR2; serrate; SRRT | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Application | ELISA, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 623-872 of human SRRT (NP_001122325.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9BXP5 | Immunogen Sequence |
Uniprot Id
Q9BXP5
Target Species
Human
Target Name
SRRT
Target Full Name
Serrate RNA effector molecule homolog
Target Function
Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription.
Target Subcellular Location
Nucleus, nucleoplasm. Cytoplasm.
Target Protein Families
ARS2 family
Target Tissue Specificity
Ubiquitously expressed.
Target Synonyms
ARS2 protein; Arsenate resistance protein ARS2; Arsenite resistance protein 2; Arsenite resistance protein; Arsenite-resistance protein 2; ASR2; MGC126427; Serrate; Serrate RNA effector molecule; Serrate RNA effector molecule homolog (Arabidopsis); Serrate RNA effector molecule homolog; SRRT; SRRT_HUMAN
Target Background
Enables mRNA cap binding complex binding activity and protein-macromolecule adaptor activity. Involved in primary miRNA processing. Located in nucleoplasm. Part of ribonucleoprotein complex.
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