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The antibody against SS18 was raised in rabbit using the Peptide sequence around aa.14~18(G-E-I-T-P) derived from Human SYT. as the immunogen. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. This antibody has been validated on ELISA, WB.
The antibody against SS18 was raised in rabbit using the Peptide sequence around aa.14~18(G-E-I-T-P) derived from Human SYT. as the immunogen. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. This antibody has been validated on ELISA, WB.
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Western blot analysis of extracts from A431 cells using SYT Antibody.
| Cat.No | ADC-43086A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SS18 |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+) | Purification Method | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Peptide sequence around aa.14~18(G-E-I-T-P) derived from Human SYT. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q15532 |
Uniprot Id
Q15532
Target Species
Human
Target Name
SS18
Target Full Name
Protein SSXT
Target Function
Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner.
Target Involvement
A chromosomal aberration involving SS18 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency).
Target Subcellular Location
Nucleus.
Target Protein Families
SS18 family
Target Tissue Specificity
Fairly ubiquitously expressed. Expressed in synovial sarcomas and in other human cell lines. The fusion genes SSXT-SSX1 and SSXT-SSX2 are expressed only in synovial sarcomas.
Target Synonyms
MGC116875; Protein SSXT; Protein SYT; SS18; SSXT; SSXT/SSX4v fusion ; SSXT_HUMAN; Synovial sarcoma translocated to X chromosome; Synovial sarcoma translocated to X chromosome protein; Synovial sarcoma translocation chromosome 18; SYT; SYT SSX1; SYT SSX2; SYT/SSX4v fusion protein; SYTSSX1; SYTSSX2
Target Background
Enables nuclear receptor coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Part of SWI/SNF complex. Implicated in synovial sarcoma.
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