Rabbit anti-Human SSTR1 Polyclonal Antibody

Uniprot Id

P30872

Target Species

Human

Target Name

SSTR1

Target Full Name

Somatostatin receptor type 1

Target Function

Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

G-protein coupled receptor 1 family

Target Tissue Specificity

Fetal kidney, fetal liver, and adult pancreas, brain, lung, jejunum and stomach.

Target Synonyms

SSTR1; Somatostatin receptor type 1; SS-1-R; SS1-R; SS1R; SRIF-2

Target Background

Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. The protein encoded by this gene is a member of the superfamily of somatostatin receptors having seven transmembrane segments. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This somatostatin receptor has greater affinity for somatostatin-14 than -28.