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The antibody against ST5 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human ST5. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
The antibody against ST5 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human ST5. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
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Western Blot analysis of COLO205 cells using ST5 Polyclonal Antibody
Western Blot analysis of K562 cells using ST5 Polyclonal Antibody2
| Cat.No | ADC-37562A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ST5 |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Isotype | IgG | Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the Internal region of Human ST5. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P78524 |
Uniprot Id
P78524
Target Species
Human
Target Name
DENND2B
Target Full Name
DENN domain-containing protein 2B
Target Function
May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane.; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.; May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable).
Target Subcellular Location
[Isoform 1]: Cytoplasm, cell cortex. Cell membrane. Recycling endosome.
Target Tissue Specificity
Widely expressed with the exception of peripheral blood lymphocytes. Isoform 1 is expressed in several epithelial and fibroblast (including tumorigenic) but absent in lymphoid cell lines (at protein level). Isoform 3 is expressed in primary cell or weakly
Target Synonyms
DENND2B; DENN domain containing protein 2B; DENN domain-containing protein 2B; DENN/MADD domain containing 2B ; HeLa tumor suppression 1; HTS1; p126; ST 5; ST5; ST5_HUMAN; Suppression of tumorigenicity 5; Suppression of tumorigenicity 5 protein
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