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The antibody against ST6GALNAC3 was raised in rabbit using the Recombinant Human Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 protein (40-305AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against ST6GALNAC3 was raised in rabbit using the Recombinant Human Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 protein (40-305AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-18965A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ST6GALNAC3 |
| Target Synonyms | 6-sialyltransferase 3 antibody; EC 2.4.99.7 antibody; GalNAc alpha-2, 6-sialyltransferase III antibody; ST6GalNAc III antibody; ST6GalNAcIII antibody; STY antibody; Sialyltransferase 7C antibody; SIAT7-C antibody, ST6GALNAC3 antibody; SIAT7C antibody; UNQ2787/PRO7177Alpha-N-acetylgalactosaminide alpha-2 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 protein (40-305AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8NDV1 |
Uniprot Id
Q8NDV1
Target Species
Human
Target Name
ST6GALNAC3
Target Full Name
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
Target Function
Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of glycoproteins and glycolipids forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto a GalNAc residue inside the backbone core chains. ST6GalNAcIII prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b. GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis. Sialylation of glycoproteins or glycosphingolipids is very important in tumor development, neuronal development, nerve repair, immunological processes and regulation of hormone sensitivity.
Target Subcellular Location
Golgi apparatus membrane; Single-pass type II membrane protein.
Target Protein Families
Glycosyltransferase 29 family
Target Tissue Specificity
Expressed in brain and kidney. Observed in the epithelium of the proximal tubules, marginal expression was also found in the distal tubules and collecting tubules.
Target Synonyms
ST6GALNAC3; SIAT7C; UNQ2787/PRO7177Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; EC 2.4.99.7; GalNAc alpha-2,6-sialyltransferase III; ST6GalNAc III; ST6GalNAcIII; STY; Sialyltransferase 7C; SIAT7-C
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