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The antibody against ST8SIA1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 49-270 of human ST8SIA1 (NP_003025.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against ST8SIA1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 49-270 of human ST8SIA1 (NP_003025.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-00954A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ST8SIA1 |
| Target Synonyms | GD3S; SIAT8; SIAT8A; SIAT8-A; ST8SiaI; ST8SIA1 | Form | Liquid |
| Species Reactivity | Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse kidney | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 49-270 of human ST8SIA1 (NP_003025.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q92185 | Immunogen Sequence |
Uniprot Id
Q92185
Target Species
Human
Target Name
ST8SIA1
Target Full Name
Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase
Target Function
Catalyzes the addition of sialic acid in alpha 2,8-linkage to the sialic acid moiety of the ganglioside GM3 to form ganglioside GD3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid. Can catalyze the addition of a second alpha-2,8-sialic acid to GD3 to form GT3. Can use GM1b, GD1a and GT1b as acceptor substrates to synthesize GD1c, GT1a and GQ1b respectively. Can synthesize unusual tetra- and pentasialylated lactosylceramide derivatives identified as GQ3 (II3Neu5Ac4-Gg2Cer) and GP3 (II3Neu5Ac5-Gg2Cer) in breast cancer cells.
Target Subcellular Location
Golgi apparatus membrane; Single-pass type II membrane protein.
Target Protein Families
Glycosyltransferase 29 family
Target Tissue Specificity
Strongly expressed in melanoma cell lines, adult and fetal brain and to a lesser extent in adult and fetal lung.
Target Synonyms
8-sialyltransferase 8A; 8-sialyltransferase; Alpha 2,8 sialyltransferase 8A; Alpha N acetylneuraminide alpha 2,8 sialyltransferase; Alpha-2; Alpha-N-acetylneuraminide alpha-2; Disialoganglioside (GD3) synthase; Ganglioside GD3 synthase; Ganglioside GT3 synthase; Ganglioside specific alpha 2,8 polysialyltransferase; GD3S; SIA8A_HUMAN; Sialyltransferase 8 (alpha N acetylneuraminate: alpha 2,8 sialytransferase, GD3 synthase) A; Sialyltransferase 8A (alpha N acetylneuraminate: alpha 2,8 sialyltransferase, GD3 synthase); Sialyltransferase 8A; Sialytransferase St8Sia I; SIAT8; SIAT8-A; SIAT8A; ST8 alpha N acetyl neuraminide alpha 2,8 sialyltransferase 1; ST8 alpha N acetyl neuraminide alpha 28 sialyltransferase 1; ST8Sia I; ST8SIA1; ST8SiaI
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