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The antibody against STAT5B was raised in rabbit using the Synthesized non-phosphopeptide derived from Human STAT5B around the phosphorylation site of serine 731(A-P-S-P-A). as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IHC.
The antibody against STAT5B was raised in rabbit using the Synthesized non-phosphopeptide derived from Human STAT5B around the phosphorylation site of serine 731(A-P-S-P-A). as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IHC.
$297.00
Western blot analysis of extracts from RAW264.7 cells, treated with EGF (200ng/ml 30min), using STAT5B (Ab-731) antibody.
Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using STAT5B (Ab-731) antibody.2
| Cat.No | ADC-42633A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | STAT5B |
| Target Synonyms | Signal transducer and activator of transcription 5B antibody; STA5B_HUMAN antibody; STAT5 antibody; Stat5b antibody; Transcription factor STAT5B antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized non-phosphopeptide derived from Human STAT5B around the phosphorylation site of serine 731(A-P-S-P-A). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P51692 |
Uniprot Id
P51692
Target Species
Human
Target Name
STAT5B
Target Full Name
Signal transducer and activator of transcription 5B
Target Function
Carries out a dual signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation.
Target Involvement
Growth hormone insensitivity with immunodeficiency (GHII)
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
Transcription factor STAT family
Target Synonyms
Signal transducer and activator of transcription 5B; STA5B_HUMAN; STAT5; Stat5b; Transcription factor STAT5B
Target Background
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
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