Name: Rabbit anti-Human STK36 Polyclonal Antibody
SKU: ADC-35600A
Availability: InStock

Rabbit anti-Human STK36 Polyclonal Antibody

The antibody against STK36 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human STK36. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, ELISA.

ADC-35600A

$167.00

Number

Cat.No

ADC-35600A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

STK36

Target Synonyms

FU antibody; Fused homolog antibody; KIAA1278 antibody; Serine/threonine kinase 36, fused homolog antibody; Serine/threonine protein kinase 36 fused homolog antibody; Serine/threonine-protein kinase 36 antibody; STK36 antibody; STK36_HUMAN antibody

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate

Non-conjugated

Application

ELISA, IHC, WB

Storage

Upon receipt

Immunogen Description

Synthesized peptide derived from the Internal region of Human STK36.

Target Species

Human

Immunogen Sequence

Complete sequences for the immunogen, target protein, and peptides are available upon request.

Uniprot ID

Q9NRP7

Background Information

Uniprot Id

Q9NRP7
Target Species

Human
Target Name

STK36
Target Full Name

Serine/threonine-protein kinase 36
Target Function

Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Essential for construction of the central pair apparatus of motile cilia.
Target Subcellular Location

Cytoplasm. Nucleus.
Target Protein Families

Protein kinase superfamily, Ser/Thr protein kinase family
Target Tissue Specificity

Expressed at low levels in most fetal tissues, adult ovaries and at high levels in adult testis, where it is localized in germ cells.
Target Synonyms

FU; Fused homolog; KIAA1278; Serine/threonine kinase 36, fused homolog; Serine/threonine protein kinase 36 fused homolog; Serine/threonine-protein kinase 36; STK36; STK36_HUMAN
Target Background

This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants.

Rabbit anti-Human STK36 Polyclonal Antibody

Specifications

Immunogen Information

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