Rabbit anti-Human STRA6 Polyclonal Antibody

Uniprot Id

Q9BX79

Target Species

Human

Target Name

STRA6

Target Full Name

Receptor for retinol uptake STRA6

Target Function

Functions as retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1. Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A. Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin. Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid. STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency. Does not transport retinoic acid.

Target Involvement

Microphthalmia, syndromic, 9 (MCOPS9)

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Tissue Specificity

Broad expression. In adult eye expressed in sclera, retina, retinal pigment epithelium, and trabecular meshwork but not in choroid and iris.

Target Research Area

Developmental Biology

Target Synonyms

MCOPCB8; MCOPS9; PP14296; Stimulated by retinoic acid 6 homolog; Stimulated by retinoic acid gene 6 protein homolog; STRA6; STRA6_HUMAN

Target Background

The protein encoded by this gene is a membrane protein involved in the metabolism of retinol. The encoded protein acts as a receptor for retinol/retinol binding protein complexes. This protein removes the retinol from the complex and transports it across the cell membrane. Defects in this gene are a cause of syndromic microphthalmia type 9 (MCOPS9). Several transcript variants encoding a few different isoforms have been found for this gene.