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The antibody against STX12 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-276 of human STX12 (NP_803173.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against STX12 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-276 of human STX12 (NP_803173.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-00023A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | STX12 |
| Target Synonyms | STX13; STX14; STX12 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse kidney, Mouse brain, Rat kidney | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-276 of human STX12 (NP_803173.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q86Y82 | Immunogen Sequence |
Uniprot Id
Q86Y82
Target Species
Human
Target Name
STX12
Target Full Name
Syntaxin-12
Target Function
SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting.
Target Subcellular Location
Endosome membrane; Single-pass type IV membrane protein. Golgi apparatus membrane; Single-pass type IV membrane protein. Endomembrane system; Single-pass type IV membrane protein; Cytoplasmic side. Early endosome membrane; Single-pass type IV membrane protein. Recycling endosome membrane; Single-pass type IV membrane protein.
Target Protein Families
Syntaxin family
Target Synonyms
MGC51957; Stx12; STX12_HUMAN; STX13; STX14; Syntaxin-12
Target Background
Predicted to enable SNAP receptor activity and SNARE binding activity. Involved in autophagosome assembly; cholesterol efflux; and protein stabilization. Located in several cellular components, including membrane raft; phagocytic vesicle; and phagophore assembly site. Part of SNARE complex. Colocalizes with BLOC-1 complex.
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