Rabbit anti-Human SULT1A3 Polyclonal Antibody

Uniprot Id

P0DMM9

Target Species

Human

Target Name

SULT1A3

Target Full Name

Sulfotransferase 1A3

Target Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs.

Target Subcellular Location

Cytoplasm.

Target Protein Families

Sulfotransferase 1 family

Target Tissue Specificity

Liver, colon, kidney, lung, brain, spleen, small intestine, placenta and leukocyte.

Target Research Area

Neuroscience

Target Synonyms

SULT1A3; STM; Sulfotransferase 1A3; ST1A3; EC 2.8.2.1; Aryl sulfotransferase 1A3/1A4; Catecholamine-sulfating phenol sulfotransferase; HAST3; M-PST; Monoamine-sulfating phenol sulfotransferase; Placental estrogen sulfotransferase; Sulfotransferase 1A3/1A4; Sulfotransferase; monoamine-preferring; Thermolabile phenol sulfotransferase; TL-PST

Target Background

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16; this gene and SULT1A4 arose from a segmental duplication. This gene is the most centromeric of the four sulfotransferase genes. Read-through transcription exists between this gene and the upstream SLX1A (SLX1 structure-specific endonuclease subunit homolog A) gene that encodes a protein containing GIY-YIG domains.