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The antibody against SUMF2 was raised in rabbit using the Recombinant Human Sulfatase-modifying factor 2 protein (26-301AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, antigen affinity purified & affinity purified with a purity greater than 95%. This antibody has been validated on ELISA, WB, IP.
The antibody against SUMF2 was raised in rabbit using the Recombinant Human Sulfatase-modifying factor 2 protein (26-301AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, antigen affinity purified & affinity purified with a purity greater than 95%. This antibody has been validated on ELISA, WB, IP.
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Western Blot | Positive WB detected in: A549 whole cell lysate, HepG2 whole cell lysate, Jurkat whole cell lysate, K562 whole cell lysate, U87 whole cell lysate, Hela whole cell lysate | All lanes: SUMF2 antibody at 1:2000 | Secondary | Goat polyclonal to rabbit IgG at 1/50000 dilution | Predicted band size: 34, 25, 38, 24, 35 kDa | Observed band size: 34 kDa
Immunoprecipitating SUMF2 in Hela whole cell lysate | Lane 1: Rabbit control IgG instead of SUMF2 Antibody in Hela whole cell lysate. | For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/50000) | Lane 2: SUMF2 Antibody (5ug) + Hela whole cell lysate (500ug) | Lane 3: Hela whole cell lysate (10ug)2
| Cat.No | ADC-00128A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SUMF2 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Antigen Affinity purified & Affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, WB, IP | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Sulfatase-modifying factor 2 protein (26-301AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8NBJ7 |
Uniprot Id
Q8NBJ7
Target Species
Human
Target Name
SUMF2
Target Full Name
Inactive C-alpha-formylglycine-generating enzyme 2
Target Function
Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1.
Target Subcellular Location
Endoplasmic reticulum lumen.
Target Protein Families
Sulfatase-modifying factor family
Target Tissue Specificity
Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in kidney, liver and placenta.
Target Synonyms
SUMF2; PSEC0171; UNQ1968/PRO4500; Inactive C-alpha-formylglycine-generating enzyme 2; Paralog of formylglycine-generating enzyme; pFGE; Sulfatase-modifying factor 2
Target Background
The catalytic sites of sulfatases are only active if they contain a unique amino acid, C-alpha-formylglycine (FGly). The FGly residue is posttranslationally generated from a cysteine by enzymes with FGly-generating activity. The gene described in this record is a member of the sulfatase-modifying factor family and encodes a protein with a DUF323 domain that localizes to the lumen of the endoplasmic reticulum. This protein has low levels of FGly-generating activity but can heterodimerize with another family member - a protein with high levels of FGly-generating activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
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