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The antibody against SURF1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 80-275 of human SURF1 (NP_003163.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against SURF1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 80-275 of human SURF1 (NP_003163.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-02504A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SURF1 |
| Target Synonyms | SHY1; CMT4K; MC4DN1; SURF1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse kidney, BT-474, HL-60, Mouse liver, Rat liver, SKOV3, SW480 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 80-275 of human SURF1 (NP_003163.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | QVQRRKWKLNLIAELESRVLAEPVPLPADPMELKNLEYRPVKVRGCFDHSKELYMMPRTMVDPVREAREGGLISSSTQSGAYVVTPFHCTDLGVTILVNRGFVPRKKVNPETRQKGQIEGEVDLIGMVRLTETRQPFVPENNPERNHWHYRDLEAMARITGAEPIFIDANFQSTVPGGPIGGQTRVTLRNEHLQYI | Uniprot ID | Q15526 |
Uniprot Id
Q15526
Target Species
Human
Target Name
SURF1
Target Full Name
Surfeit locus protein 1
Target Function
Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly.
Target Involvement
Leigh syndrome (LS); Charcot-Marie-Tooth disease 4K (CMT4K)
Target Subcellular Location
Mitochondrion inner membrane; Multi-pass membrane protein.
Target Protein Families
SURF1 family
Target Synonyms
SURF1; SURF-1; Surfeit locus protein 1
Target Background
This gene encodes a protein localized to the inner mitochondrial membrane and thought to be involved in the biogenesis of the cytochrome c oxidase complex. The protein is a member of the SURF1 family, which includes the related yeast protein SHY1 and rickettsial protein RP733. The gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity, where it shares a bidirectional promoter with SURF2 on the opposite strand. Defects in this gene are a cause of Leigh syndrome, a severe neurological disorder that is commonly associated with systemic cytochrome c oxidase deficiency.
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