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The antibody against SURF1 was raised in rabbit using the Synthesized peptide derived from internal of Human SURF1. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB.
The antibody against SURF1 was raised in rabbit using the Synthesized peptide derived from internal of Human SURF1. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB.
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Western blot analysis of extracts from Jurkat cells, using SURF1 antibody.
| Cat.No | ADC-41953A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SURF1 |
| Target Synonyms | SURF1; SURF-1; Surfeit locus protein 1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from internal of Human SURF1. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q15526 |
Uniprot Id
Q15526
Target Species
Human
Target Name
SURF1
Target Full Name
Surfeit locus protein 1
Target Function
Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly.
Target Involvement
Leigh syndrome (LS); Charcot-Marie-Tooth disease 4K (CMT4K)
Target Subcellular Location
Mitochondrion inner membrane; Multi-pass membrane protein.
Target Protein Families
SURF1 family
Target Synonyms
SURF1; SURF-1; Surfeit locus protein 1
Target Background
This gene encodes a protein localized to the inner mitochondrial membrane and thought to be involved in the biogenesis of the cytochrome c oxidase complex. The protein is a member of the SURF1 family, which includes the related yeast protein SHY1 and rickettsial protein RP733. The gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity, where it shares a bidirectional promoter with SURF2 on the opposite strand. Defects in this gene are a cause of Leigh syndrome, a severe neurological disorder that is commonly associated with systemic cytochrome c oxidase deficiency.
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