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The antibody against SWAP70 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 316-585 of human SWAP70 (NP_055870.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
The antibody against SWAP70 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 316-585 of human SWAP70 (NP_055870.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
| Cat.No | ADA-05415A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SWAP70 |
| Target Synonyms | HSPC321; SWAP-70; SWAP70 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T, A-549, LO2 | Application | ELISA, WB, IF/ICC, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 316-585 of human SWAP70 (NP_055870.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9UH65 | Immunogen Sequence |
Uniprot Id
Q9UH65
Target Species
Human
Target Name
SWAP70
Target Full Name
Switch-associated protein 70
Target Function
Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion.
Target Subcellular Location
Cytoplasm. Cell membrane. Nucleus. Cell projection, lamellipodium. Cytoplasm, cytoskeleton.
Target Tissue Specificity
Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus-associated tissue. Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found in monocytes and macrophages.
Target Synonyms
KIAA0640; 70kDa; AV235546; FLJ39540; HSPC321; SWA 70 protein; SWAP 70; SWAP switching B-cell complex 70kDa subunit; SWAP-70; SWAP70; Switch associated protein 70; Switch-associated protein 70; SWP70_HUMAN
Target Background
Enables cadherin binding activity. Predicted to be involved in regulation of actin polymerization or depolymerization. Predicted to act upstream of or within isotype switching. Located in actin cytoskeleton; cytoplasm; and plasma membrane.
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