Rabbit anti-Human Synapsin II Monoclonal Antibody

Uniprot Id

Q92777

Target Species

Human

Target Name

SYN2

Target Full Name

Synapsin-2

Target Function

Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons.

Target Involvement

Schizophrenia (SCZD)

Target Subcellular Location

Cell junction, synapse.

Target Protein Families

Synapsin family

Target Tissue Specificity

Central and peripheral nervous systems.

Target Synonyms

SYN2; Synapsin-2; Synapsin II

Target Background

This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family encodes a neuron-specific phosphoprotein that selectively binds to small synaptic vesicles in the presynaptic nerve terminal. Polymorphisms in this gene are associated with abnormal presynaptic function and related neuronal disorders, including autism, epilepsy, bipolar disorder and schizophrenia. Alternative splicing of this gene results in multiple transcript variants. The tissue inhibitor of metalloproteinase 4 gene is located within an intron of this gene and is transcribed in the opposite direction.