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The antibody against TACC3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 20-140 of human TACC3 (NP_006333.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against TACC3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 20-140 of human TACC3 (NP_006333.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
Immunofluorescence analysis of U2OS cells using TACC3 Rabbit pAb at dilution of 1:100. Blue: DAPI for nuclear staining.
| Cat.No | ADA-10577A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TACC3 |
| Target Synonyms | ERIC1; Tacc4; ERIC-1; maskin; TACC3 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 20-140 of human TACC3 (NP_006333.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | CDFLFSPPEVTGRSSVLRVSQKENVPPKNLAKAMKVTFQTPLRDPQTHRILSPSMASKLEAPFTQDDTLGLENSHPVWTQKENQQLIKEVDAKTTHGILQKPVEADTDLLGDASPAFGSGS | Uniprot ID | Q9Y6A5 |
Uniprot Id
Q9Y6A5
Target Species
Human
Target Name
TACC3
Target Full Name
Transforming acidic coiled-coil-containing protein 3
Target Function
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. May be involved in the control of cell growth and differentiation. May contribute to cancer.
Target Subcellular Location
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole.
Target Protein Families
TACC family
Target Synonyms
ERIC 1; ERIC-1; ERIC1; MGC117382; MGC133242; OTTHUMP00000113796; TACC3; TACC3_HUMAN; Transforming acidic coiled coil containing protein 3; Transforming acidic coiled-coil-containing protein 3
Target Background
This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells.
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