Rabbit anti-Human TBX3 Polyclonal Antibody

Uniprot Id

O15119

Target Species

Human

Target Name

TBX3

Target Full Name

T-box transcription factor TBX3

Target Function

Transcriptional repressor involved in developmental processes. Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes. Probably plays a role in limb pattern formation. Required for mammary placode induction, and maintenance of the mammary buds during development. Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX2. Required, together with TBX2, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling. Involved in modulating early inner ear development, acting independently of, and also redundantly with, TBX2 in different subregions of the developing ear. Acts as a negative regulator of PML function in cellular senescence.

Target Involvement

Ulnar-mammary syndrome (UMS)

Target Subcellular Location

Nucleus.

Target Tissue Specificity

Widely expressed.

Target Synonyms

Bladder cancer related protein XHL; T box 3; T-box protein 3; T-box transcription factor TBX3; Tbx3; TBX3 ISO; TBX3_HUMAN; UMS; XHL

Target Background

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined.