Rabbit anti-Human TCIRG1 Polyclonal Antibody

Uniprot Id

Q13488

Target Species

Human

Target Name

TCIRG1

Target Full Name

V-type proton ATPase 116 kDa subunit a 3

Target Function

Part of the proton channel of V-ATPases. Seems to be directly involved in T-cell activation.

Target Involvement

Osteopetrosis, autosomal recessive 1 (OPTB1)

Target Subcellular Location

Membrane; Multi-pass membrane protein.

Target Protein Families

V-ATPase 116 kDa subunit family

Target Tissue Specificity

Isoform long is highly expressed in osteoclastomas. Isoform short is highly expressed in thymus.

Target Synonyms

a3; Atp 6i; Atp6i; ATP6N1C; ATP6V0A3; ATPase H+ transporting 116kD; OC 116; OC 116 kDa; OC 116kDa; OC-116 kDa; OC116; OPTB 1; OPTB1; Osteoclastic proton pump 116 kDa subunit; Specific 116 kDa vacuolar proton pump subunit; Stv 1; Stv1; T cell immune regulator 1; T cell immune regulator 1 ATPase H+ transporting lysosomal V0 subunit A; T cell immune regulator 1 ATPase H+ transporting lysosomal V0 subunit A3; T cell immune response cDNA 7; T cell immune response cDNA7 protein; T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein a; T-cell immune regulator 1; T-cell immune response cDNA7 protein; TCIRG 1; TCIRG1; TIRC 7; TIRC7; V ATPase 116 kDa; V ATPase 116 kDa isoform a3; V type proton ATPase 116 kDa subunit a; V-ATPase 116 kDa isoform a3; V-type proton ATPase 116 kDa subunit a isoform 3; Vacuolar proton translocating ATPase 116 kDa subunit A; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3; Vph 1; Vph1; VPP3_HUMAN

Target Background

This gene encodes a subunit of a large protein complex known as a vacuolar H+-ATPase (V-ATPase). The protein complex acts as a pump to move protons across the membrane. This movement of protons helps regulate the pH of cells and their surrounding environment. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. Alternative splicing results in multiple transcript variants. Mutations in this gene are associated with infantile malignant osteopetrosis.