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The antibody against TCN2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 19-250 of human TCN2 (NP_001171655.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against TCN2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 19-250 of human TCN2 (NP_001171655.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-00410A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TCN2 |
| Target Synonyms | II; TC; TC2; TC-2; TCII; TC II; D22S676; D22S750; TCN2 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse kidney, A-549, MCF7, Mouse lung, SW480, U-251MG | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 19-250 of human TCN2 (NP_001171655.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P20062 | Immunogen Sequence |
Uniprot Id
P20062
Target Species
Human
Target Name
TCN2
Target Full Name
Transcobalamin-2
Target Function
Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.
Target Involvement
Transcobalamin II deficiency (TCN2 deficiency)
Target Subcellular Location
Secreted.
Target Protein Families
Eukaryotic cobalamin transport proteins family
Target Research Area
Cardiovascular
Target Synonyms
D22S676; D22S750; II; Macrocytic anemia; OTTHUMP00000199117; OTTHUMP00000199118; OTTHUMP00000199119; TC; TC II; TC II deficiency; TC-2; TC2; TCII; TCN2; TCN2 deficiency; TCO2_HUMAN; Transcobalamin 2; Transcobalamin 2 deficiency; Transcobalamin II; Transcobalamin II; macrocytic anemia; Transcobalamin-2; Vitamin B12 binding protein 2
Target Background
This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants.
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