Rabbit anti-Human TCP1 alpha Monoclonal Antibody

The antibody against TCP1 alpha was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-100 of human TCP1 alpha (P17987) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-13433A

Number

Cat.No	ADA-13433A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	TCP1 alpha
Target Synonyms	CCT1; CCTa; D6S230E; CCT-alpha; TCP-1-alpha; TCP1 alpha	Form	Liquid
Species Reactivity	Human	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	Jurkat	Application	ELISA, WB, IHC-P

Cat.No

ADA-13433A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

TCP1 alpha

Target Synonyms

CCT1; CCTa; D6S230E; CCT-alpha; TCP-1-alpha; TCP1 alpha

Form

Liquid

Species Reactivity

Human

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

Jurkat

Application

ELISA, WB, IHC-P

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TCP1 alpha (P17987).	Target Species	Human
Immunogen Sequence	MEGPLSVFGDRSTGETIRSQNVMAAASIANIVKSSLGPVGLDKMLVDDIGDVTITNDGATILKLLEVEHPAAKVLCELADLQDKEVGDGTTSVVIIAAEL	Uniprot ID	P17987

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TCP1 alpha (P17987).

Target Species

Human

Immunogen Sequence

MEGPLSVFGDRSTGETIRSQNVMAAASIANIVKSSLGPVGLDKMLVDDIGDVTITNDGATILKLLEVEHPAAKVLCELADLQDKEVGDGTTSVVIIAAEL

Uniprot ID

P17987

Background Information

Uniprot Id

P17987
Target Species

Human
Target Name

TCP1
Target Full Name

T-complex protein 1 subunit alpha
Target Function

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
Target Subcellular Location

Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Target Protein Families

TCP-1 chaperonin family
Target Synonyms

AI528772; c-cpn; CCT alpha; CCT; CCT-alpha; CCT1; Ccta; CCTalpha; D6S230E; MGC133746; p63; T complex 1; T complex protein 1 alpha subunit; T complex protein 1; T-complex homolog TCP1; T-complex protein 1 subunit alpha; T-complex protein 1 subunit alpha B; Tailless complex polypeptide 1; Tailless complex polypeptide 1A; Tailless complex polypeptide 1B; TCP 1 alpha; Tcp-1; TCP-1-alpha; TCP1; TCPA_HUMAN; Tp63; TRic
Target Background

The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found.

Rabbit anti-Human TCP1 alpha Monoclonal Antibody

Specifications

Immunogen Information

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