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The antibody against TCTA was raised in rabbit using the Recombinant Human T-cell leukemia translocation-altered gene protein (62-103AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against TCTA was raised in rabbit using the Recombinant Human T-cell leukemia translocation-altered gene protein (62-103AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
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Immunohistochemistry of paraffin-embedded human adrenal gland tissue using TCTA Antibody at dilution of 1:1002
| Cat.No | ADC-21321A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TCTA |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human T-cell leukemia translocation-altered gene protein (62-103AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P57738 |
Uniprot Id
P57738
Target Species
Human
Target Name
TCTA
Target Full Name
T-cell leukemia translocation-altered gene protein
Target Function
May be required for cellular fusion during osteoclastogenesis.
Target Involvement
A chromosomal aberration involving TCTA is associated with T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(1;3)(p34;p21).
Target Subcellular Location
Membrane; Multi-pass membrane protein.
Target Protein Families
TCTA family
Target Tissue Specificity
Ubiquitous. Highest level of expression in kidney. Present in monocytes, osteoclasts, macrophages, synoviocytes and synovial lining cells (at protein level).
Target Synonyms
T-cell leukemia translocation altered gene; T-cell leukemia translocation-altered gene protein; T-cell leukemia translocation-associated gene protein; Tcta; TCTA_HUMAN
Target Background
Involved in negative regulation of osteoclast differentiation and osteoclast fusion. Predicted to be integral component of membrane.
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