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The antibody against TDGF1 was raised in rabbit using the Recombinant Human Teratocarcinoma-derived growth factor 1 protein (32-150AA) as the immunogen. This antibody exists as a fitc conjugated isotype IgG, purified by protein G with a purity greater than 95%.
The antibody against TDGF1 was raised in rabbit using the Recombinant Human Teratocarcinoma-derived growth factor 1 protein (32-150AA) as the immunogen. This antibody exists as a fitc conjugated isotype IgG, purified by protein G with a purity greater than 95%.
$299.00
| Cat.No | ADC-50337A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TDGF1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | FITC conjugated |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Teratocarcinoma-derived growth factor 1 protein (32-150AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P13385 |
Uniprot Id
P13385
Target Species
Human
Target Name
CRIPTO
Target Full Name
Protein Cripto
Target Function
GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated TDGF1 acts as a Nodal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells. Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.
Target Subcellular Location
Cell membrane; Lipid-anchor, GPI-anchor. Secreted.
Target Protein Families
EGF-CFC (Cripto-1/FRL1/Cryptic) family
Target Tissue Specificity
Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung.
Target Research Area
Developmental Biology
Target Synonyms
CR; CRGF; Cripto 1; Cripto 1 growth factor; cripto; Cripto-1 growth factor; Cripto1 growth factor; Epidermal growth factor like cripto protein CR1; Epidermal growth factor-like cripto protein CR1; TDGF 1; TDGF1; TDGF1_HUMAN; Teratocarcinoma derived growth factor 1; Teratocarcinoma-derived growth factor 1
Target Background
This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants.
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