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The antibody against TECPR1 was raised in rabbit using the Recombinant Human Tectonin beta-propeller repeat-containing protein 1 protein (199-487AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against TECPR1 was raised in rabbit using the Recombinant Human Tectonin beta-propeller repeat-containing protein 1 protein (199-487AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human heart tissue using TECPR1 Antibody at dilution of 1:100
Immunofluorescent analysis of A375 cells using TECPR1 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)2
| Cat.No | ADC-15275A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TECPR1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Tectonin beta-propeller repeat-containing protein 1 protein (199-487AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q7Z6L1 |
Uniprot Id
Q7Z6L1
Target Species
Human
Target Name
TECPR1
Target Full Name
Tectonin beta-propeller repeat-containing protein 1
Target Function
Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation.
Target Subcellular Location
Cytoplasmic vesicle, autophagosome membrane. Lysosome membrane. Note=Localizes to Lysosome membranes, and binds PtdIns(3)P at the surface of autophagosome. Localizes to autolysosomes, a vesicle formed by the fusion between autophagosomes and lysosomes.
Target Protein Families
TECPR1 family
Target Synonyms
2210010N04Rik; DKFZP434B0335; FLJ23419; FLJ90593; KIAA1358; MGC124730; mKIAA1358; RGD1306873; TCPR1_HUMAN; Tecpr1; tectonin beta propeller repeat containing 1; Tectonin beta-propeller repeat-containing protein 1
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