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The antibody against TERB1 was raised in rabbit using the Recombinant Human Telomere repeats-binding bouquet formation protein 1 protein (301-550AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against TERB1 was raised in rabbit using the Recombinant Human Telomere repeats-binding bouquet formation protein 1 protein (301-550AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human ovarian cancer using TERB1 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human prostata cancer using TERB1 Antibody at dilution of 1:1002
| Cat.No | ADC-19074A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TERB1 |
| Target Synonyms | TERB1 antibody; CCDC79 antibody; Telomere repeats-binding bouquet formation protein 1 antibody; Coiled-coil domain-containing protein 79 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Telomere repeats-binding bouquet formation protein 1 protein (301-550AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8NA31 |
Uniprot Id
Q8NA31
Target Species
Human
Target Name
TERB1
Target Full Name
Telomere repeats-binding bouquet formation protein 1
Target Function
Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the MAJIN-TERB1-TERB2 complex, TERB1 probably mediates association with the shelterin/telosome complex via interaction with TERF1, promoting priming telomeric DNA attachment'. Promotes telomere association with the nuclear envelope and deposition of the SUN-KASH/LINC complex. Also recruits cohesin to telomeres to develop structural rigidity.
Target Subcellular Location
Chromosome, telomere. Nucleus inner membrane.
Target Protein Families
TERB1 family
Target Synonyms
TERB1; CCDC79; Telomere repeats-binding bouquet formation protein 1; Coiled-coil domain-containing protein 79
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