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The antibody against TESC was raised in rabbit using the Recombinant Human Calcineurin B homologous protein 3 protein (2-214AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IF.
The antibody against TESC was raised in rabbit using the Recombinant Human Calcineurin B homologous protein 3 protein (2-214AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IF.
$299.00
Immunofluorescent analysis of A549 cells using TESC Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
| Cat.No | ADC-44829A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TESC |
| Target Synonyms | TESC antibody; CHP3Calcineurin B homologous protein 3 antibody; Tescalcin antibody; TSC antibody | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Calcineurin B homologous protein 3 protein (2-214AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q96BS2 |
Uniprot Id
Q96BS2
Target Species
Human
Target Name
TESC
Target Full Name
Calcineurin B homologous protein 3
Target Function
Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin.
Target Subcellular Location
Nucleus. Cytoplasm. Membrane; Lipid-anchor. Cell membrane. Cell projection, lamellipodium. Cell projection, ruffle membrane.
Target Protein Families
Calcineurin regulatory subunit family, CHP subfamily
Target Tissue Specificity
Expressed in mature megakaryocytes and polymorphonuclear granulocytes (at protein level). Abundantly expressed in heart. Also expressed at a lower level in adult testis and salivary gland, and in the placenta.
Target Research Area
Signal Transduction
Target Synonyms
TESC; CHP3Calcineurin B homologous protein 3; Tescalcin; TSC
Target Background
Enables calcium ion binding activity. Involved in several processes, including cellular response to retinoic acid; positive regulation of macromolecule metabolic process; and positive regulation of myeloid cell differentiation. Located in several cellular components, including cytosol; lamellipodium; and nucleoplasm.
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