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The antibody against TESK1 was raised in rabbit using the Synthesized peptide derived from internal of Human TESK1. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB.
The antibody against TESK1 was raised in rabbit using the Synthesized peptide derived from internal of Human TESK1. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB.
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Western blot analysis of extracts from rat heart cells, rat kidney cells and rat liver cells, using TESK1 antibody.
| Cat.No | ADC-41259A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TESK1 |
| Target Synonyms | TESK1 antibody; Dual specificity testis-specific protein kinase 1 antibody; EC 2.7.12.1 antibody; Testicular protein kinase 1 antibody | Form | Liquid |
| Species Reactivity | Human | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from internal of Human TESK1. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q15569 |
Uniprot Id
Q15569
Target Species
Human
Target Name
TESK1
Target Full Name
Dual specificity testis-specific protein kinase 1
Target Function
Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity. Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1. Positively regulates integrin-mediated cell spreading, via phosphorylation of cofilin. Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1. Probably plays a central role at and after the meiotic phase of spermatogenesis.
Target Subcellular Location
Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, lamellipodium.
Target Protein Families
Protein kinase superfamily, TKL Ser/Thr protein kinase family
Target Tissue Specificity
Expressed in podocytes and renal tubular cells in the kidney (at protein level).
Target Synonyms
TESK1; Dual specificity testis-specific protein kinase 1; EC 2.7.12.1; Testicular protein kinase 1
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