Mouse anti-Human TF Monoclonal Antibody

Uniprot Id

P02787

Target Species

Human

Target Name

TF

Target Full Name

Serotransferrin

Target Function

Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.; (Microbial infection) Serves as an iron source for Neisseria species, which capture the protein and extract its iron for their own use.

Target Involvement

Atransferrinemia (ATRAF)

Target Subcellular Location

Secreted.

Target Protein Families

Transferrin family

Target Tissue Specificity

Expressed by the liver and secreted in plasma.

Target Synonyms

TFQTL1; PRO1557; PRO2086; HEL-S-71p; Transferrin

Target Background

This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum.