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The antibody against TFB2M was raised in rabbit using the Recombinant Human Dimethyladenosine transferase 2, mitochondrial protein (30-108AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against TFB2M was raised in rabbit using the Recombinant Human Dimethyladenosine transferase 2, mitochondrial protein (30-108AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-11610A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TFB2M |
| Target Synonyms | N''-adenosyl(rRNA) dimethyltransferase 2 antibody; S adenosylmethionine 6 N' | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Biotin conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Dimethyladenosine transferase 2, mitochondrial protein (30-108AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9H5Q4 |
Uniprot Id
Q9H5Q4
Target Species
Human
Target Name
TFB2M
Target Full Name
Dimethyladenosine transferase 2, mitochondrial
Target Function
S-adenosyl-L-methionine-dependent rRNA methyltransferase which may methylate two specific adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 12S mitochondrial rRNA (Probable). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Stimulates transcription independently of the methyltransferase activity.
Target Subcellular Location
Mitochondrion.
Target Protein Families
Class I-like SAM-binding methyltransferase superfamily, rRNA adenine N(6)-methyltransferase family, KsgA subfamily
Target Tissue Specificity
Ubiquitously expressed.
Target Synonyms
N''-adenosyl(rRNA) dimethyltransferase 2; S adenosylmethionine 6 N', N' adenosyl(rRNA) dimethyltransferase 2; Dimethyladenosine transferase 2; dimethyladenosine transferase 2 mitochondrial; FLJ22661; FLJ23182; h mtTFB; h mtTFB2; h-mtTFB; h-mtTFB2; HCV NS5A transactivated protein 5; HCV NS5A-transactivated protein 5; hepatitis C virus NS5A transactivated protein 5; Hepatitis C virus NS5A-transactivated protein 5; Hkp1; hTFB2M; Mitochondrial 12S rRNA dimethylase 2; mitochondrial; Mitochondrial dimethyladenosine transferase 2; Mitochondrial transcription factor B2; mtTFB; mtTFB2; NS5ATP5; S-adenosylmethionine-6-N''; TFB2M; TFB2M_HUMAN; Transcription Factor B2; Transcription factor B2 mitochondrial
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