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The antibody against TFR2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 130-330 of human TFR2 (NP_003218.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
The antibody against TFR2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 130-330 of human TFR2 (NP_003218.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
| Cat.No | ADA-08906A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TFR2 |
| Target Synonyms | HFE3; TFRC2; TFR2 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | K-562, Mouse liver | Application | ELISA, WB, IF/ICC, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 130-330 of human TFR2 (NP_003218.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9UP52 | Immunogen Sequence |
Uniprot Id
Q9UP52
Target Species
Human
Target Name
TFR2
Target Full Name
Transferrin receptor protein 2
Target Function
Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation.
Target Involvement
Hemochromatosis 3 (HFE3)
Target Subcellular Location
Cell membrane; Single-pass type II membrane protein.; [Isoform Beta]: Cytoplasm. Note=Lacks the transmembrane domain. Probably intracellular.
Target Protein Families
Peptidase M28 family, M28B subfamily
Target Tissue Specificity
Predominantly expressed in liver. While the alpha form is also expressed in spleen, lung, muscle, prostate and peripheral blood mononuclear cells, the beta form is expressed in all tissues tested, albeit weakly.
Target Synonyms
HFE 3; HFE3; MGC126368; TFR 2; TfR2; TFR2_HUMAN; TFRC 2; TFRC2; Transferrin receptor 2; Transferrin receptor protein 2
Target Background
This gene encodes a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. This protein mediates cellular uptake of transferrin-bound iron, and may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
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